hört sich mal gut an das Gw1516 aber man bekommt es irgendwie nirgends, ist immer ausverkauft
FORTES FORTUNA ADIUVAT
Denkt mal haarscharf nach.I am actually doing research on this compound and AICAR, and know the other people that have done research on gw501516.
The study you refer too was outdated. It was believed that it formed polyps in the colon and could cause colon cancer, the pathway was studied as it acts as a popular cholesterol medicine attacking a paar-gamma receptor. However its mechanism of action is still not fully understood.
The drug has been admister as high as 10 mg per g per body weight in genetically obese mice, obese mice, mice following a obese diet, people. In mice it did not affect insulin in genetically obese mice (we inject them as babies so their brain cannot develop a certain area that controls weight), but it did affect obese and diet induced obese mice.
In people 10 mg a day was found to reverse the metabolic syndrome (it did the job of 4 medicines).
After we give the mice the medicine for 12+ weeks in a row I killed them, and examine colon, made their liver into a pulp, brown fat and white fat (iBAT and eWAT) and examine it for differences and markers. There no traces of cancer, but a clear decrease in fat and LDH, and 40 % increase in HDL.
Is this definite proof... no, but this medicine has "medical" potential maybe not for BB industry for certainly for people suffering with the compound of the metabolic syndrome.
I've work my ass off so that drug companies come back and re test them. The funny thing is they are ok investigating a drug that reduces cholesterol but has 3 more sides effects vs this one that could "cure" it alltogether. So maybe, just maybe glaxo smith is looking out for glaxo smith profits, and not you and me.
My actual mice... are cancer free...too bad I still have to kill them.